Chapter 31 – Transcription Factors

摘要: Publisher Summary This chapter reviews the physiological function of transcription factors in normal cells and role some that may be relevant pathogenesis asthma chronic obstructive pulmonary disease (COPD). Asthma COPD are characterized by an increased expression components inflammatory cascade. The these proteins seen is result enhanced gene transcription. Transcription regulate many genes, including play a key since they underlie acute mechanisms characterize diseases. amplify perpetuate process, so it possible abnormal functioning determine severity response to treatment. Several new compounds based on interacting with specific or their activation pathways now development for treatment COPD, drugs already clinical use thought work via factors. In future genetic regulation increasingly important aspect research, as this one critical regulating phenotypes responsiveness therapy.