The efficacy of antigen-specific immunoadsorption and rebound of anti-A/B antibodies in ABO-incompatible kidney transplantation

摘要: Background. As antigen-specific immunoadsorption (IA) using the Glycosorb-ABO columns is becoming increasingly popular in ABO-incompatible (ABOi) transplantation, this study, we retrospectively investigated efficacy of IA vivo and ex .W e also assessed risk anti-A/B antibody (ABab) rebound before after ABOi kidney transplantation. Methods. A protocol for living donor transplantation was used, combining four preoperative three preemptive postoperative IAs with rituximab maintenance immunosuppression. ABabs were determined by a haemagglutination titration technique. Results. attempted 45 times 43 transplantations performed. Overall patient survival 93% graft 91%. Mean followup 4.5 years. significantly reduced majority patients (P < 0.0001). However, (6.8%), elimination incomplete. Inadequate adsorption core-chain-dependent may explain finding, but further studies are needed. In five patients, preconditioning interrupted resulting ABab rebound. Yet, when restarted, antibodies could be removed as planned. After seen two (5%). Conclusions. combination effectively depletes most owing to ABabs, GlycosorbABO less effective than nonspecific techniques removal some patients. Rebound subsequent does not hamper successful Postoperatively, followed, small.