Antipyretic and analgesic methods and compositions containing optically pure r(-)ketoprofen
作者： William J. Wechter , Nancy M. Gray , James W. Young
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摘要: Methods and compositions are disclosed utilizing optically pure R(-) ketoprofen for the treatment of pain including, but not limited to, associated with toothaches, headaches, sprains, joint post-surgical pain, example dental ophthalmic while substantially reducing adverse effects gastrointestinal, renal hepatic toxicities, leukopenia, which administration racemic ketoprofen. Optically is also useful in treating pyrexia
lens.org 参考文章(44)
Donald F. Smith, Handbook of stereoisomers: therapeutic drugs CRC Press. ,(1989)
Abraham Sunshine, Eugene M. Laska, Sustained/enhanced analgesia ,(1989)
Karl-Ernst Schulte, Gottfried Blaschke, Process for obtaining enantiomers of 2-arylpropionic acids ,(1989)
Charles M. Zepp, Stephen A. Wald, Stephen L. Matson, David R. Dodds, Method for resolution of stereoisomers ,(1988)
C.M. Markey, A. Alward, P.E. Weller, L.J. Marnett, Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities. Journal of Biological Chemistry. ,vol. 262, pp. 6266- 6279 ,(1987) , 10.1016/S0021-9258(18)45564-0
Abraham Sunshine, Eugene M. Laska, Onset-hastened/enhanced analgesia ,(1987)
Angel Gusman, Francisco Yuste, Ruben A. Toscano, John M. Young, Absolute configuration of (−)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac Journal of Medicinal Chemistry. ,vol. 29, pp. 589- 591 ,(1986) , 10.1021/JM00154A027
Andrew J. Hutt, John Caldwell, The importance of stereochemistry in the clinical pharmacokinetics of the 2-arylpropionic acid non-steroidal anti-inflammatory drugs. Clinical Pharmacokinectics. ,vol. 9, pp. 371- 373 ,(1984) , 10.2165/00003088-198409040-00007
K. Brune, W. S. Beck, G. Geisslinger, S. Menzel-Soglowek, B. M. Peskar, B. A. Peskar, Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition. Cellular and Molecular Life Sciences. ,vol. 47, pp. 257- 261 ,(1991) , 10.1007/BF01958153
Matthew R. Wright, Neal M. Davies, Fakhreddin Jamali, Rationale for the Development of Stereochemically Pure Enantiomers: Are the R Enantiomers of Chiral Nonsteroidal Anti-Inflammatory Drugs Inactive? Journal of Pharmaceutical Sciences. ,vol. 83, pp. 911- 912 ,(1994) , 10.1002/JPS.2600830631