The interaction between P2X7Rs and T-type calcium ion channels in penicillin-induced epileptiform activity.
作者： Gokhan Arslan , Bahattin Avci , Süleyman Emre Kocacan , Emil Rzayev , Mustafa Ayyildiz
DOI: 10.1016/J.NEUROPHARM.2019.01.027
关键词:
摘要: Abstract Limited information exists on the link between purinergic class P2X7 receptors (P2X7Rs) and calcium ion channels in epilepsy; no data has been reported regarding interaction P2X7Rs T-type epilepsy. Thus, this study is an evaluation of role that play effect penicillin-induced epileptiform activity. In first set experiments, P2X7R agonist BzATP (at 25-, 50-, 100- 200-μg doses), antagonist A-438079 5-, 10-, 20- 40-μg doses) channel antagonist, NNC-550396 were administered for electrophysiological analyses 30 min after penicillin injection (2.5 μl, 500 IU). second effective doses these substances used biochemical analyses. Malondialdehyde (MDA), advanced oxidation protein product (AOPP), glutathione (GSH), reductase (GR), peroxide (GPx), catalase (CAT) superoxide dismutase (SOD) levels measured cerebrum, cerebellum brainstem rats. (100 μg, icv) increased mean frequency activity, whereas (40 μg, (30 μg, ic) reduced it. Both reversed BzATP's proconvulsant action. lipid peroxidation oxidation; it also altered other antioxidant enzymes study, which all then via NNC-550396, at least cerebrum. The analysis present suggest its with important experimental model
sci-hub.se 参考文章(51)
Ryan L. O’Hare Doig, Wissam Chiha, Marcus K. Giacci, Nathanael J. Yates, Carole A. Bartlett, Nicole M. Smith, Stuart I. Hodgetts, Alan R. Harvey, Melinda Fitzgerald, Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma BMC Neuroscience. ,vol. 18, pp. 62- 62 ,(2017) , 10.1186/S12868-017-0380-1
Juliane Proft, Yuriy Rzhepetskyy, Joanna Lazniewska, Fang-Xiong Zhang, Stuart M. Cain, Terrance P. Snutch, Gerald W. Zamponi, Norbert Weiss, The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca 2+ currents by altering calnexin-dependent trafficking of Ca v 3.2 channels Scientific Reports. ,vol. 7, pp. 11513- 11513 ,(2017) , 10.1038/S41598-017-11591-5
Stuart M. Cain, John R. Tyson, Hyun-Beom Choi, Rebecca Ko, Paulo J. C. Lin, Jeffrey M. LeDue, Kim L. Powell, Louis-Philippe Bernier, Ravi L. Rungta, Yi Yang, Pieter R. Cullis, Terence J. O'Brien, Brian A. MacVicar, Terrance P. Snutch, Ca(V)3.2 drives sustained burst-firing, which is critical for absence seizure propagation in reticular thalamic neurons Epilepsia. ,vol. 59, pp. 778- 791 ,(2018) , 10.1111/EPI.14018
Yingfei Xiong, Sasa Teng, Lianghong Zheng, Suhua Sun, Jie Li, Ning Guo, Mingli Li, Li Wang, Feipeng Zhu, Changhe Wang, Zhiren Rao, Zhuan Zhou, Stretch-induced Ca2+ independent ATP release in hippocampal astrocytes. The Journal of Physiology. ,vol. 596, pp. 1931- 1947 ,(2018) , 10.1113/JP275805
Maho Shibata, Eisuke Ishizaki, Ting Zhang, Masanori Fukumoto, Alma Barajas-Espinosa, Tong Li, Donald Puro, Purinergic Vasotoxicity: Role of the Pore/Oxidant/KATP Channel/Ca2+ Pathway in P2X7-Induced Cell Death in Retinal Capillaries Vision (Basel, Switzerland). ,vol. 2, pp. 25- ,(2018) , 10.3390/VISION2030025
Shailendra S Handu, Prashant Sharma, Pramod K Mediratta, Qazi Mushtaq Ahmed, Seema Jain, Aditya J Reddy, Ashok Kumar Dubey, Anticonvulsant and Antioxidant Effects of Musa sapientum Stem Extract on Acute and Chronic Experimental Models of Epilepsy Pharmacognosy Research. ,vol. 10, pp. 49- 54 ,(2018) , 10.4103/PR.PR_31_17
D. Bravo, C.J. Maturana, T. Pelissier, A. Hernández, L. Constandil, Interactions of pannexin 1 with NMDA and P2X7 receptors in central nervous system pathologies: Possible role on chronic pain. Pharmacological Research. ,vol. 101, pp. 86- 93 ,(2015) , 10.1016/J.PHRS.2015.07.016
Kim L. Powell, Stuart M. Cain, Terrance P. Snutch, Terence J. O'Brien, Low threshold T‐type calcium channels as targets for novel epilepsy treatments British Journal of Clinical Pharmacology. ,vol. 77, pp. 729- 739 ,(2014) , 10.1111/BCP.12205
Beáta Sperlágh, Attila Köfalvi, Jim Deuchars, Lucy Atkinson, Carol J. Milligan, Noel J. Buckley, E. Sylvester Vizi, Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus Journal of Neurochemistry. ,vol. 81, pp. 1196- 1211 ,(2002) , 10.1046/J.1471-4159.2002.00920.X
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)