Anticonvulsant and Antioxidant Effects of Musa sapientum Stem Extract on Acute and Chronic Experimental Models of Epilepsy
作者： Shailendra S Handu , Prashant Sharma , Pramod K Mediratta , Qazi Mushtaq Ahmed , Seema Jain
DOI: 10.4103/PR.PR_31_17
关键词: Malondialdehyde 、 Kindling 、 Glutathione 、 Oxidative stress 、 Anticonvulsant 、 Epilepsy 、 Convulsion 、 Pharmacology 、 Antioxidant 、 Medicine
摘要: Background: Musa sapientum (banana) plant extract has been shown to possess antioxidant activity in previous studies. Neuronal injury resulting from oxidative stress is an important factor involved pathogenesis of epilepsy. Objective: The present study aimed evaluate the anticonvulsant M. stem (MSSE) acute and chronic experimental models mice its effects on various markers brain pentylenetetrazole (PTZ)-kindled animals. Material Methods: Maximal electroshock seizures (MES) PTZ-induced convulsion were used for For study, effect MSSE development kindling was studied. evaluation brain, malondialdehyde (MDA) reduced glutathione (GSH) levels estimated brains kindled Results: significantly increased latency onset myoclonic jerks duration clonic convulsions following PTZ administration. pretreated group showed mean seizure score kindling. There a significant increase MDA decrease GSH response On pretreatment, there brains, though not significant. Conclusion: results this suggest presence MSSE, both models, which could be due activity, as reflected by change brain.
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