Immunomodulatory cell therapy in sepsis: have we learnt lessons from the past?

摘要: Sepsis still constitutes a public health challenge worldwide since its incidence constantly increases over time but related mortality remains more or less constant. There is thus an unquestionable and urgent need to develop innovative efficacious therapies for the treatment of this deadly disease. In study, authors propose that injection mesenchymal stem cells rescues mice from death after septic shock owing their potent immunosuppressive anti-inflammatory properties. The conclude immunomodulatory cell therapy may represent effective sepsis. While potential therapeutic value these not be challenged, considering present lack convincing data about use in sepsis, we do believe they constitute next topical clinical trial field. Rather, recent evidence indicates most patients actually with profound immune alterations suggesting approaches could deleteriously amplify state. Therefore, article, hypotheses explaining why future trials sepsis immunology will likely rely on stimulating functions rebalancing homeostasis.