Human Milk Oligosaccharides Protect Against Enteropathogenic Escherichia coli Attachment In Vitro and EPEC Colonization in Suckling Mice
作者： Carolin F. Manthey , Chloe A. Autran , Lars Eckmann , Lars Bode
DOI: 10.1097/MPG.0000000000000172
关键词:
摘要: Breast-feeding reduces the risk of enteric bacterial infections in newborns part because human milk oligosaccharides (HMOs), complex glycans that are present milk, but not infant formula. Enteropathogenic Escherichia coli (EPEC) attaching/effacing pathogens cause serious diarrheal illness with potentially high mortality infants. We isolated HMOs from pooled and found they significantly reduce EPEC attachment to cultured epithelial cells. In suckling mice, administration reduced colonization compared untreated controls. These data suggest an essential role for prevention
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