Bone morphology allows estimation of loading history in a murine model of bone adaptation

摘要: Bone adapts its morphology (density/micro- architecture) in response to the local loading conditions such a way that uniform tissue is achieved (‘Wolff’s law’). This paradigm has been used as basis for bone remodeling simulations predict formation and adaptation of trabecular bone. However, order architectural changes patients, physiological external conditions, which was adapted, need be determined. In present study, we developed novel estimation method by calculating history produces most loading. We applied this murine caudal vertebrae two groups were vivo loaded either 0 or 8 N, respectively. Plausible load cases sequentially micro-finite element models mice vertebrae, scaling factors calculated each case derive strain-energy density when all scaled are simultaneously. The able difference correct magnitude group. result suggests can estimated from could useful predicting studies at sites where measurements difficult, fossil bones.