Longitudinal assessment of in vivo bone dynamics in a mouse tail model of postmenopausal osteoporosis.
作者： Floor M. Lambers , Gisela Kuhn , Friederike A. Schulte , Kathleen Koch , Ralph Müller
DOI: 10.1007/S00223-011-9553-6
关键词:
摘要: Recently, it has been shown that transient bone biology can be observed in vivo using time-lapse micro-computed tomography (μCT) the mouse tail bone. Nevertheless, order for to a model human disease, hallmarks of any disease must mimicked. The aim this study was investigate whether postmenopausal osteoporosis could modeled caudal vertebrae C57Bl/6 mice, considering static and dynamic morphometry as well mechanical properties, describe temporal changes remodeling rates. Twenty mice were ovariectomized (OVX, n = 11) or sham-operated (SHM, 9) monitored with μCT on day surgery every 2 weeks after, up 12 weeks. There significant decrease volume fraction OVX (−35%) compared SHM (+16%) trabecular (P < 0.001). For OVX, high-turnover loss observed, resorption rate exceeding formation Furthermore there whole-bone stiffness (−16%) (+11%, P From these results we conclude vertebra mimics respect parameters therefore might suitable osteoporosis. When evaluating rates, found caused an immediate increase 0.001) delayed Monitoring is promising method future research.
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