Short-Term Treatment of Recombinant Murine Interleukin-4 Rapidly Inhibits Bone Formation in Normal and Ovariectomized Mice
作者： Y Okada , I Morimoto , K Ura , Y Nakano , Y Tanaka
DOI: 10.1016/S8756-3282(97)00296-2
关键词:
摘要: Estrogen deficiency contributes to an increase in bone resorption and formation characterized by a high rate of turnover. Interleukin-4 (IL-4) is rapid potent inhibitor resorption. We examined the short term vivo effects recombinant murine IL-4 (rmIL-4) on remodeling normal ovariectomized mice. Eight-week-old mice were randomized into following five groups: (1) sham-operated (sham); (2) infused with rmIL-4; (3) (ovx); (4) ovx (5) replaced 10 or 20 μg 17β-estradiol (E2) for 14 28 days after ovariectomy, respectively. rmIL-4 at dose 5 μg/day was sham 3 prior sacrifice. Analyses performed operation. An serum alkaline phosphatase urinary deoxypyridinoline levels induced ovariectomy inhibited 3-day infusion rmIL-4. In ovx, IL-6 also increased significantly which restored E2 but not Histomorphometrical analysis trabecular revealed that turnover such as osteoclastic surface (Oc.S/BS), number osteoclasts per mm (N.Oc/BS), mineralized (MS/BS), mineral apposition (MAR). A significant decrease volume (BV/TV) observed modulated sham, caused Oc.S/BS, N.Oc/BS, MS/BS, MAR, BV/TV conclude rapidly inhibits only its both growing mice, resulting low without modulating volume.
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