Postpubertal architectural developmental patterns differ between the L3 vertebra and proximal tibia in three inbred strains of mice.

摘要: An understanding of normal microarchitectural bone development patterns common murine models is needed. Longitudinal, structural, and mineralization trends were evaluated by in vivo microCT over 12 time points from 6-48 wk age at the vertebra tibia C3H/HeN, C57BL/6, BALB/C mice. Longitudinal growth occurred rapidly until 8-10 wk, slowed as plate bridged, fused mo. Structural augmentation through formation trabeculae thickening existing ones. In vertebrae, BV/TV increased all strains. Between 32 architecture was stable with deviating <1.1%, 1.6%, 3.4% for BALB/C, C3H/HeN contrast, tibial changed continuously but more moderately TbTh compared comparable or larger changes TbN TbSp. Age-related trabecular deterioration (decreased TbN; TbSp structure model index) evident both sites wk. strains, cortex continued to develop after values peaked. The temporal plateau BMD variable across mouse strains site, whereas tissue mineral density attained approximately 6 mo Geometric diaphysis providing C57BL/6 mice highest torsional compressive rigidity, respectively. summary, key skeletal milestones identified, architectural topology found be than tibia.