Sex differences in Sjögren’s syndrome: a comprehensive review of immune mechanisms

摘要: Autoimmune diseases (ADs) are estimated to affect between 5 and 8 % of the US population, approximately 80 % these patients women. Sjogren’s syndrome (SS) is an AD that occurs predominately in women over men (16:1). The hallmark characteristic SS diminished secretory production from primary exocrine gland lacrimal or salivary glands resulting symptoms dry eye mouth. disease believed be mediated by inflammatory autoantibody response directed against tissues. This review will examine literature on sex differences immune animal models order gain a better understanding pathogenesis.