Interventions for men and women with their first episode of genital herpes

摘要: Background Genital herpes is incurable, and caused by the simplex virus (HSV). First-episode genital first clinical presentation of that a person experiences. Current treatment based around viral suppression in order to decrease length severity episode. Objectives To determine effectiveness safety different existing treatments for first-episode on duration symptoms time recurrence. Search methods We searched Cochrane Central Register Controlled Trials (CENTRAL) (from inception April 2016), MEDLINE Specialised Sexually Transmitted Infections Review Group EMBASE PsycINFO CINAHL LILACS AMED Alternative Medicines 2016). We handsearched number relevant journals, reference lists all included studies, databases ongoing trials, other Internet databases. Selection criteria We randomised controlled trials (RCTs) participants with herpes. excluded vaccination which primary objective assessed complication HSV infection. Data collection analysis All studies written English were independently at least two review authors inclusion, risk bias each trial, extract data. Studies requiring translation trial quality, data extraction external translators. Main results We 26 2084 analysed. Most conducted United Kingdom (UK) States (US), involved men women experiencing their episode herpes, exception three only women. rated majority these as having an unclear bias; largely due lack information supplied publications, age trials. This found low quality evidence from oral acyclovir, when compared placebo, reduced individuals undergoing (mean difference (MD) -3.22, 95% confidence interval (CI) -5.91 -0.54; I2 = 52%). In (112 participants), intravenous acyclovir decreased median days patients suffered symptoms. Oral valaciclovir (converted acyclovir) also showed similar symptom studies. There currently no topical reduces (MD -0.61 days, CI -2.16 0.95; 3 RCTs, 195 participants, statistic 56%). There current cicloxolone cream, carbenoxolone sodium adenosine arabinoside, idoxuridine dimethyl sulfoxide, placebo people herpes. Two reported reduction recurrence following versus placebo. Adverse events generally poorly we unable quantitatively analyse this outcome. For those taking there serious adverse events; most common coryza, dizziness, tiredness, diarrhoea renal colic. phlebitis, nausea abnormal liver function tests was pain application.Those interferon had significantly more placebo. Authors' conclusions There However, did not show antivirals limited inclusion skewed data, resulting few able meta-analyse.