Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions

摘要: Background: In humans elective spine surgery can cause iatrogenic spinal cord injury (SCI). Efforts for neuroprotection have been directed to avoid mechanical by using intraoperative monitoring and improving surgical techniques. There is, however, uncertainty regarding the efficacy of neuroprotective drugs. Study design: Experimental study on effectiveness pharmacological in an animal model simulating anticipated mechanically induced neurological damage. Objective: To compare four drugs protect against effects SCI. Setting: Research Unit Neurological Diseases, IMSS-Proyecto Camina, Mexico City, Mexico. Methods: Erythropoietin, melatonin, cyclosporine-A methylprednisolone were administered rats before, during after controlled contusion mild intensity. Dosage was accordance with their pharmacokinetic properties experience gained experimental Drug assessed motor function recovery over a period 6 weeks morphometry. Results: Compared animals treated saline, drug-treated groups showed no differences locomotor performance, nor amount spared tissue. Notably, spontaneous activity significantly reduced cyclosporine-A. Conclusion: The neuroprotectant used here perioperatively did not reduce extent damage Therefore, now, only protection is avoidance primary altogether.