Prophylactic neuroprotection with A91 improves the outcome of spinal cord injured rats.
作者： A. Ibarra , M. Sosa , E. García , A. Flores , Y. Cruz
DOI: 10.1016/J.NEULET.2013.08.048
关键词:
摘要: Abstract Iatrogenic injury to the spinal cord (SC) is not an uncommon complication of surgery. In attempt establish a preventive therapy for anticipated SC injury, we tested effect single dose (SD) vaccine vs. addition booster (BD) neural-derived peptide (A91) prior contusion. Immunization with A91 immediately after has demonstrated induce significant tissue protection and motor recovery. After only BD vaccination schedule had neuroprotective effect. It was capable improving neurological recovery that always significantly higher than one observed in rats SD immunization or those treated PBS. Toward end study, animals presented BBB score 9.75 ± 0.17 (mean ± standard deviation) while PBS 6.6 ± 0.7 5.6 ± 0.6 respectively. next step attempted corroborate induced by immunization. For this purpose, assessed survival rubrospinal neurons (RSNs) ventral horn (VHNs) sixty days injury. both RSNs VHNs Finally, failure success (SD respectively) associated lower A91-specific T cell proliferation. Prophylactic neuroprotection initial subsequent may improve sustained during invasive surgery procedures.
elsevier.com
sci-hub.se 参考文章(20)
S. Martiñon, E. García, N. Flores, I. Gonzalez, T. Ortega, M. Buenrostro, R. Reyes, A. M. Fernandez-Presas, G. Guizar-Sahagún, D. Correa, A. Ibarra, Vaccination with a neural-derived peptide plus administration of glutathione improves the performance of paraplegic rats. European Journal of Neuroscience. ,vol. 26, pp. 403- 412 ,(2007) , 10.1111/J.1460-9568.2007.05650.X
I. Shaked, D. Tchoresh, R. Gersner, G. Meiri, S. Mordechai, X. Xiao, R. P. Hart, M. Schwartz, Protective autoimmunity: Interferon-γ enables microglia to remove glutamate without evoking inflammatory mediators Journal of Neurochemistry. ,vol. 92, pp. 997- 1009 ,(2005) , 10.1111/J.1471-4159.2004.02954.X
G Guízar-Sahagún, C A Rodríguez-Balderas, R E Franco-Bourland, A Martínez-Cruz, I Grijalva, A Ibarra, I Madrazo, Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions Spinal Cord. ,vol. 47, pp. 156- 160 ,(2009) , 10.1038/SC.2008.85
Antonio Ibarra, Dolores Correa, Kaethe Willms, Marie Therese Merchant, Gabriel Guı́zar-Sahagún, Israel Grijalva, Ignacio Madrazo, None, Effects of cyclosporin-A on immune response, tissue protection and motor function of rats subjected to spinal cord injury Brain Research. ,vol. 979, pp. 165- 178 ,(2003) , 10.1016/S0006-8993(03)02898-1
K.-S. Delank, H. W. Delank, D. P. K�nig, F. Popken, S. F�rderer, P. Eysel, Iatrogenic paraplegia in spinal surgery Archives of Orthopaedic and Trauma Surgery. ,vol. 125, pp. 33- 41 ,(2005) , 10.1007/S00402-004-0763-5
Y. Ziv, H. Avidan, S. Pluchino, G. Martino, M. Schwartz, Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 13174- 13179 ,(2006) , 10.1073/PNAS.0603747103
E Hauben, U Nevo, E Yoles, G Moalem, E Agranov, F Mor, S Akselrod, M Neeman, IR Cohen, M Schwartz, Autoimmune T cells as potential neuroprotective therapy for spinal cord injury The Lancet. ,vol. 355, pp. 286- 287 ,(2000) , 10.1016/S0140-6736(99)05140-5
María del Rayo Garrido, Raúl Silva-García, Elisa García, Susana Martiñón, Mariana Morales, Humberto Mestre, Carmina Flores-Domínguez, Adrian Flores, Antonio Ibarra, Therapeutic Window for Combination Therapy of A91 Peptide and Glutathione Allows Delayed Treatment After Spinal Cord Injury Basic & Clinical Pharmacology & Toxicology. ,vol. 112, pp. 314- 318 ,(2013) , 10.1111/BCPT.12023
M Alcanyis-Alberola, M Giner-Pascual, S Salinas-Huertas, M Gutiérrez-Delgado, Iatrogenic spinal cord injury: an observational study. Spinal Cord. ,vol. 49, pp. 1188- 1192 ,(2011) , 10.1038/SC.2011.72
E. Hauben, A. Ibarra, T. Mizrahi, R. Barouch, E. Agranov, M. Schwartz, Vaccination with a Nogo-A-derived peptide after incomplete spinal-cord injury promotes recovery via a T-cell-mediated neuroprotective response: Comparison with other myelin antigens Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 15173- 15178 ,(2001) , 10.1073/PNAS.011585298