Age-related differences in the neutrophil response to pulmonary pseudomonas infection

摘要: Abstract Background Pseudomonas aeruginosa pneumonia is more common and lethal in the elderly. The immunologic underpinnings of this increased incidence mortality have not been evaluated, however are assumed to be a complication age-associated immune dysfunction. Methods Young (10–12 week old) aged (18–20 month BALB/c mice were subjected intratracheal infection P. . Animals sacrificed 24 h after inoculation. lungs collected for analysis lung pathology, chemokine levels, neutrophil counts, myeloperoxidase activity. Results Pulmonary levels KC significantly higher relative young following P infection. Despite this, counts compared Furthermore, neutrophils predominantly found air space infected mice. This correlated with activity from bronchoalveolar lavage specimens Conclusions Neutrophil migration into impaired despite elevated suggesting that immunosenescence impairing migration.