The CorA Mg2+ Transporter Does Not Transport Fe2+

摘要: corA encodes the constitutively expressed primary Mg2+ uptake system of most eubacteria and many archaea. Recently, a mutation in was reported to make Salmonella enterica serovar Typhimurium markedly resistant Fe2+-mediated toxicity. Mechanistically, this hypothesized be from an ability CorA mediate influx Fe2+. Consequently, we directly examined Fe2+ transport toxicity wild-type versus cells. As determined by direct assay, cannot does not potently inhibit 63Ni2+. can, relatively weakly, uptake, but inhibition is dependent on presence functional allele. Although excess slightly toxic S. Typhimurium, were unable elicit significant differential sensitivity strain. We conclude that relationship, if any, between iron indirect.