A rationale for chemoradiation (vs radiotherapy) in salivary gland cancers? On behalf of the REFCOR (French rare head and neck cancer network)

摘要: Abstract Background Salivary gland carcinomas constitute a heterogeneous group of tumors, with over 20 histological subtypes various prognoses. The mainstay treatment is surgery, radiotherapy advocated for unresectable disease or postoperatively in case poor prognostic factors such as high grade, locally advanced and/or incompletely resected tumors. Concurrent chemotherapy sometimes routine practice based on criteria extrapolated from squamous cell the head and neck, radioresistance salivary tumors results obtained metastatic setting. aim this review was to identify situations where advocated. Material methods A search literature performed following key words: parotid, gland, neoplasm, cancer, malignant tumor, chemoradiation, chemotherapy, treatment. Case report studies published before 2000 were not included. Results Platinum-based regimens most frequent. Other reported seemed dependent histology. level evidence concurrent delivery radiation therapy supported by low evidence. Prescribing mostly relies similar those used indicate dose radiotherapy. Protocols vary Conclusion rationale adding remains be demonstrated prospectively. Although type systemic treatments may adapted histology, strongest favor cisplatin.