Relapsing high grade mucoepidermoid carcinoma. Long-lasting complete response following reirradiation and EGFR blockade.
作者： D. Milanovic , B. Jeremic , G. Kayser , H.C. Rischke , J. Pfeiffer
DOI: 10.1007/S00066-012-0096-1
关键词: Internal medicine 、 Epidermal growth factor receptor 、 Carcinoma 、 Monoclonal 、 Oncology 、 Cetuximab 、 Radiation therapy 、 Blockade 、 Mucoepidermoid carcinoma 、 Hard palate 、 Medicine
摘要: Background and purpose The treatment strategy for inoperable recurrent mucoepidermoid carcinoma (MEC) is not well established. Here, we present a case of relapsed high grade MEC the salivary glands hard palate that was successfully treated with reirradiation (re-RT) cetuximab, an antibody against epidermal growth factor receptor (EGFR).
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sci-hub.se 参考文章(29)
Susanne Burdak-Rothkamm, Claudia E. Rübe, Tan Phu Nguyen, Daniela Ludwig, Klaus Feldmann, Thomas Wiegel, Christian Rübe, Radiosensitivity of tumor cell lines after pretreatment with the EGFR tyrosine kinase inhibitor ZD1839 (Iressa). Strahlentherapie Und Onkologie. ,vol. 181, pp. 197- 204 ,(2005) , 10.1007/S00066-005-1319-5
Nele Platteaux, Piet Dirix, Bianca Vanstraelen, Sandra Nuyts, Outcome after Re-Irradiation of Head and Neck Cancer Patients Strahlentherapie und Onkologie. ,vol. 187, pp. 23- 31 ,(2011) , 10.1007/S00066-010-2139-9
Edgar Selzer, Susanne Liederer, Christiane Lemaire, Gerhard Kren, Dejan Radonjic, Gabriela Kornek, Thomas Knocke, Richard Pötter, Barbara Bachtiary, Incidence of dermatitis in head and neck cancer patients treated with primary radiotherapy and cetuximab. Strahlentherapie Und Onkologie. ,vol. 187, pp. 373- 377 ,(2011) , 10.1007/S00066-011-2217-7
Klaus Dittmann, Claus Mayer, H. Peter Rodemann, Nuclear EGFR as novel therapeutic target: insights into nuclear translocation and function. Strahlentherapie Und Onkologie. ,vol. 186, pp. 1- 6 ,(2010) , 10.1007/S00066-009-2026-4
Panagiotis Balermpas, Markus Hambek, Oliver Seitz, Claus Rödel, Christian Weiss, Combined Cetuximab and Reirradiation for Locoregional Recurrent and Inoperable Squamous Cell Carcinoma of the Head and Neck Strahlentherapie Und Onkologie. ,vol. 185, pp. 775- 781 ,(2009) , 10.1007/S00066-009-2092-7
Felix Zwicker, Falk Roeder, Christian Thieke, Carmen Timke, Marc W. Münter, Peter E. Huber, Jürgen Debus, IMRT Reirradiation with Concurrent Cetuximab Immunotherapy in Recurrent Head and Neck Cancer Strahlentherapie und Onkologie. ,vol. 187, pp. 32- 38 ,(2011) , 10.1007/S00066-010-2149-7
Horst Buerger, Frank Gebhardt, Hartmut Schmidt, Burkhard Brandt, Werner Boecker, Kirsten Hutmacher, Alf Beckmann, Ralph Lelle, Ronald Simon, Length and Loss of Heterozygosity of an Intron 1 Polymorphic Sequence of egfr Is Related to Cytogenetic Alterations and Epithelial Growth Factor Receptor Expression Cancer Research. ,vol. 60, pp. 854- 857 ,(2000)
B. S. Glisson, G. Blumenschein, M. Francisco, J. Erasmus, R. Zinner, M. Kies, Phase II trial of gefitinib in patients with incurable salivary gland cancer Journal of Clinical Oncology. ,vol. 23, pp. 5532- 5532 ,(2005) , 10.1200/JCO.2005.23.16_SUPPL.5532
Scott A. Laurie, Lisa Licitra, Systemic Therapy in the Palliative Management of Advanced Salivary Gland Cancers Journal of Clinical Oncology. ,vol. 24, pp. 2673- 2678 ,(2006) , 10.1200/JCO.2005.05.3025
Lynette M Sholl, A John Iafrate, Yi-Ping Chou, Ming-Tsang Wu, Yih-Gang Goan, Li Su, Yen-Tsung Huang, David C Christiani, Lucian R Chirieac, Validation of chromogenic in situ hybridization for detection of EGFR copy number amplification in nonsmall cell lung carcinoma. Modern Pathology. ,vol. 20, pp. 1028- 1035 ,(2007) , 10.1038/MODPATHOL.3800946