A fast track strategy toward highly functionalized dendrimers with different structural layers: an “onion peel approach”

摘要: An accelerated strategy depending on different chemical building blocks between each layer, coined “onion peel”, was used to construct a library of third generation dendrimers with 108, 180 and 252 hydroxyl surface groups using combination microwave assisted highly efficient CuAAC thiol–ene reactions. These were conveniently acquired high purity good yields in divergent manner variety orthogonal dense AB3, AB5, AB7 blocks. The resulting polyhydroxylated tested several human cell types did not impair mitochondrial metabolic function or viability suggesting that they are candidates for applications biological investigations.