Satiation attenuates BOLD activity in brain regions involved in reward and increases activity in dorsolateral prefrontal cortex: an fMRI study in healthy volunteers

摘要: BACKGROUND: Neural responses to rewarding food cues are significantly different in the fed vs. fasted (>8 h food-deprived) state. However, effect of eating satiety after a shorter (more natural) intermeal interval on neural both and aversive has not been examined. OBJECTIVE: With use novel functional magnetic resonance imaging (fMRI) task, we investigated satiation tastes pictures. DESIGN: Sixteen healthy participants (8 men, 8 women) were scanned 2 separate test days, before meal or for 4 (satiated premeal). fMRI blood oxygen level-dependent (BOLD) signals sight and/or taste stimuli recorded. RESULTS: A whole-brain cluster-corrected analysis (P < 0.05) showed that attenuated BOLD response stimulus types ventromedial prefrontal cortex (vmPFC), orbitofrontal cortex, nucleus accumbens, hypothalamus, insula but increased activity dorsolateral (dlPFC; local maxima corrected P ≤ 0.001). psychophysiological interaction vmPFC was more highly connected dlPFC when individuals exposed satiated than satiated. CONCLUSIONS: These results suggest natural attenuates reward-related brain regions increases dlPFC, which may reflect "top down" cognitive influence satiation. This trial registered at clinicaltrials.gov as NCT02298049.