Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins.
作者： Zakey Yusuf Buuh , Zhigang Lyu , Rongsheng E. Wang
DOI: 10.1021/ACS.JMEDCHEM.6B01817
关键词:
摘要: Post-translational modifications (PTMs) allot versatility to the biological functions of highly conserved proteins. Recently, non-histone proteins such as methylation, acetylation, phosphorylation, glycosylation, ubiquitination, and many more have been linked regulation pivotal pathways related cellular response stability. Due roles these dynamic assume, their dysregulation has associated with cancer other important diseases inflammatory disorders neurodegenerative diseases. For this reason, we present a review perspective on post-translational proteins, emphasis in small molecule inhibitors developed target PTM writers. Certain PTMs’ contribution epigenetics extensively expounded; yet efforts will be needed systematically dissect especially for relationships nononcological disease...
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