Constraints on lateral gene transfer in promoting fimbrial usher protein diversity and function

摘要: Fimbriae are long, adhesive structures widespread throughout members of the family Enterobacteriaceae. They multimeric extrusions, which moved out bacterial cell through an integral outer membrane protein called usher. The complex folding mechanics usher were recently revealed to be catalysed by membrane-embedded translocation and assembly module (TAM). Here, we examine diversity proteins across a wide range extraintestinal (ExPEC) enteropathogenic (EPEC) Escherichia coli, further focus on so far undescribed chaperone-usher system, with this referred as UshC. fimbrial system containing UshC is distributed discrete set EPEC types, including model strains like E2348/67, well ExPEC ST131, currently most prominent multi-drug-resistant uropathogenic E. coli strain worldwide. Deletion TAM from naive results in drastic time delay UshC, can observed for two introduced related organisms, Yersinia Enterobacter We suggest that models why machinery essential efficient acquired via lateral gene transfer.