Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner

Cancer Genome Atlas Research Network, None, Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia The New England Journal of Medicine. ,vol. 368, pp. 2059- 2074 ,(2013) , 10.1056/NEJMOA1301689

H Honda, A Nagamachi, T Inaba, -7/7q- syndrome in myeloid-lineage hematopoietic malignancies: attempts to understand this complex disease entity. Oncogene. ,vol. 34, pp. 2413- 2425 ,(2015) , 10.1038/ONC.2014.196

Bowen Xu, Kyle D. Konze, Jian Jin, Gang Greg Wang, Targeting EZH2 and PRC2 dependence as novel anticancer therapy. Experimental Hematology. ,vol. 43, pp. 698- 712 ,(2015) , 10.1016/J.EXPHEM.2015.05.001

Thomas Ernst, Andrew J Chase, Joannah Score, Claire E Hidalgo-Curtis, Catherine Bryant, Amy V Jones, Katherine Waghorn, Katerina Zoi, Fiona M Ross, Andreas Reiter, Andreas Hochhaus, Hans G Drexler, Andrew Duncombe, Francisco Cervantes, David Oscier, Jacqueline Boultwood, Francis H Grand, Nicholas C P Cross, Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders Nature Genetics. ,vol. 42, pp. 722- 726 ,(2010) , 10.1038/NG.621

T. Neff, A. U. Sinha, M. J. Kluk, N. Zhu, M. H. Khattab, L. Stein, H. Xie, S. H. Orkin, S. A. Armstrong, Polycomb repressive complex 2 is required for MLL-AF9 leukemia Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 5028- 5033 ,(2012) , 10.1073/PNAS.1202258109

S L Peters, R A Hlady, J Opavska, D Klinkebiel, S J Pirruccello, G A Talmon, J G Sharp, L Wu, R Jaenisch, M A Simpson, A R Karpf, R Opavsky, Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis. Leukemia. ,vol. 28, pp. 1138- 1142 ,(2014) , 10.1038/LEU.2013.364

O Abdel-Wahab, A Pardanani, J Patel, M Wadleigh, T Lasho, A Heguy, M Beran, D G Gilliland, R L Levine, A Tefferi, Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms Leukemia. ,vol. 25, pp. 1200- 1202 ,(2011) , 10.1038/LEU.2011.58

A Pellagatti, M Cazzola, A Giagounidis, J Perry, L Malcovati, M G Della Porta, M Jädersten, S Killick, A Verma, C J Norbury, E Hellström-Lindberg, J S Wainscoat, J Boultwood, Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells Leukemia. ,vol. 24, pp. 756- 764 ,(2010) , 10.1038/LEU.2010.31

Bowen Xu, Doan M. On, Anqi Ma, Trevor Parton, Kyle D. Konze, Samantha G. Pattenden, David F. Allison, Ling Cai, Shira Rockowitz, Shichong Liu, Ying Liu, Fengling Li, Masoud Vedadi, Stephen V. Frye, Benjamin A. Garcia, Deyou Zheng, Jian Jin, Gang Greg Wang, Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia Blood. ,vol. 125, pp. 346- 357 ,(2014) , 10.1182/BLOOD-2014-06-581082

Isabel Hidalgo, Antonio Herrera-Merchan, Jose Manuel Ligos, Laura Carramolino, Javier Nuñez, Fernando Martinez, Orlando Dominguez, Miguel Torres, Susana Gonzalez, None, Ezh1 is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest. Cell Stem Cell. ,vol. 11, pp. 649- 662 ,(2012) , 10.1016/J.STEM.2012.08.001