The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene

摘要: Countless studies showed that [60]fullerene (C(60)) and derivatives could have many potential biomedical applications. However, while several independent research groups C(60) has no acute or sub-acute toxicity in various experimental models, more than 25 years after its discovery the vivo fate chronic effects of this fullerene remain unknown. If field to be fulfilled these issues must addressed. Here we show oral administration dissolved olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg body weight) rats not only does entail but it almost doubles their lifespan. The C(60)-olive solutions an model CCl(4) intoxication rat strongly suggest effect on lifespan is mainly due attenuation age-associated increases oxidative stress. Pharmacokinetic absorbed by gastro-intestinal tract eliminated a few tens hours. These results importance fields medicine toxicology should open way for possible -and waited for- applications including cancer therapy, neurodegenerative disorders, ageing.