Prescribing pattern of glucose lowering drugs in the United Kingdom in the last decade: A focus on the effects of safety warnings about rosiglitazone

摘要: Aim In the last decade, new glucose lowering drugs (GLDs) have been launched, and also several warnings regarding their safety. The cardiovascular safety of thiazolidinediones (TZD) has questioned. We analyzed prescription pattern GLDs from 2000 to November 2009 in United Kingdom (UK) using THIN database with special focus on effects about rosiglitazone issued May 2007 January 2008. Methods Annual prevalence incidence GLD prescriptions were measured. For TZD, monthly calculated 2006 2009. switching around FDA alert characteristics subjects starting treatment TZD before after alerts observed. Results The increased during 10 year period, metformin increasing more than three times. Rosiglitazone showed an trend until 2007, (2.3/1000 person-years) decreased thereafter (January 2009: 1.1/1000 person-years). use pioglitazone surpassing April 2008 onwards. sharply (0.8/1000 other therapies remained rather stable but afterwards. After users increasingly switched pioglitazone. There was proportion risk alerts. Conclusions The UK decade. TZDs, it changed as well treated them.