IL-9 protects mice from Gram-negative bacterial shock : suppression of TNF-alpha, IL-12, and IFN-gamma, and induction of IL-10.
作者： Ursula Grohmann , Jacques Van Snick , Franca Campanile , Silvia Silla , Antonio Giampietri
DOI: 10.4049/JIMMUNOL.164.8.4197
关键词:
摘要: IL-9 is a T cell-derived cytokine that, similar to the Th2 cytokines IL-4 and IL-10, has been implicated in response parasitic infections, allergy, inflammatory processes. Because both IL-10 can confer protection mice from septic shock, we investigated whether may also be capable of conferring resistance on recipients an otherwise lethal challenge with Pseudomonas aeruginosa. Prophylactic injections rIL-9 appeared most effective preventing onset according pattern that was dose dependent time dependent. The protective effect correlated marked decreases production mediators TNF-alpha, IL-12, IFN-gamma, as well induction anti-inflammatory IL-10. Sustained levels IL-9-specific transcripts could detected spleens recovering sublethal P. aeruginosa infection. Therefore, shock via rather unique mechanism involving complex modulation mediators.
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