Amygdala and hippocampal volumes in relatives of patients with bipolar disorder: a high-risk study.

摘要: Objective: Bipolar disorders (BD) have a strong genetic underpinning, yet no biological vulnerability markers for BD been identified. To test whether amygdala or hippocampal volumes represent an endophenotype BD, we measured mesiotemporal in young affected and unaffected relatives of patients with (high-risk design). Method: High-risk participants (aged 15 to 30 years) were recruited from families multiply BD. They included 20 26 offspring parents primary mood disorders, matched by age sex 31 control subjects without personal family history psychiatric disorders. Amygdala on 1.5 Tesla 3-dimensional anatomical magnetic resonance images using standard methods. Results: We found comparable among relatives, high-risk patients, subjects. The exclusion 6 medicated did not change the results. There differences between I, compared II, psychotic symptoms, symptoms. Conclusions: Hippocampal volume abnormalities absent thus meet criteria endophenotype. Can J Psychiatry. 2009;54(11):726-733. Clinical Implications * are spared early course illness. Mesiotemporal volumetric changes previously adult established do seem risk factors. Absence may suggest that structural hippocampus be preventable. Limitations This study used cross-sectional design. both I II probands. more than one subject per family. Key Words: amygdala, hippocampus, bipolar imaging, volumetry, (ProQuest: ... denotes formulae omitted.) Abbreviations this article ADHD attention-deficit hyperactivity disorder DSM Diagnostic Statistical Manual Mental Disorders KSADS-PL Schedule Affective Schizophrenia School-Age Children-Present Lifetime Version MRI imaging ROI region interest SADS-L Schizophrenia-Lifetime structures including implicated pathophysiology converging evidence structural,1 functional neuroimaging,2 neuropathological,3 neurocognitive4 studies. Structural neuroimaging findings regarding markedly heterogeneous, decreased,5-8 unchanged,9"13 as well increased14"18 relative Similarly, literature is inconsistent most studies reporting lack changes,7'14"16 but also decreased10 increased5'19 These discrepancies likely reflect clinical treatment heterogeneity.20'21 Finding abnormality which often complicated substance abuse, comorbid conditions, use combinations medications affecting brain structure, difficult. A greater problem incorporate such into pathophysiological framework. observed associated conditions effects medication, related studied …