Regulation of transcription factor function by targeted protein degradation: an overview focusing on p53, c-Myc, and c-Jun.

摘要: Regulation of protein degradation is an important mechanism by which concentrations proteins controlled in cells. In addition to involved cell cycle regulation or mitosis, levels many transcription factors are regulated targeted proteosomal degradation. and stability usually linked post-translational modification the target phosphorylation. The resulting phosphoaminoacid context adjacent sequence then recognized E3 ubiquitin ligase enzymes that covalently attach small thereby direct them be degraded proteosomes. Here, we present overview mechanisms regulating p53, c-Myc, c-Jun factors. Especially, purpose highlight role phosphorylation these We also examples where can either enhance inhibit Lastly, discuss common theme among N-terminal both increases transactivation capacity protects from proteolytic