Unexpected equilibria resulting from differing growth rates of subpopulations within heterogeneous tumors

摘要: Abstract A mathematical model which describes the emergence of a new tumor subpopulation from homogeneous neoplasm was used to study compositional equilibria in heterogeneous tumors. The dependence on and repopulation rates special interest that, some circumstances, even when emergent ( S 1 ) exhibited accelerated regrowth (as after exposure differential cytotoxicity) equilibrium mix shifted towards slower-growing original 2 ). It also observed those cases that faster rate for , greater shift is predominantly composed cells appears be. Therefore, if competitive dynamics are displayed between subpopulations tumor, one should not necessarily expect predictable end population knowledge growth kinetics by individuals subclones. clinical experimental consequences within this type microecology discussed.