Loss of chromosome 11p alleles in cultured cells derived from Wilms' tumours.

摘要: Cell cultures have been produced from five Wilms' tumours. All had a finite lifespan and pattern of antigen expression which indicated that the cells were derived differentiated components No showed any expected characteristics putative tumour stem cell. Nevertheless, in both cases where original tumours loss heterozygosity at chromosome 11p alleles, cultured also demonstrated heterozygosity. Thus these cell definitely originated tissue. The results demonstrate can be tissues present non-immortal show no 'transformed' phenotype, even though they possess genetic changes tumour.