Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke
作者： Thiruma V Arumugam , Sic L Chan , Dong-Gyu Jo , Gokhan Yilmaz , Sung-Chun Tang
DOI: 10.1038/NM1403
关键词:
摘要: Mice transgenic for antisense Notch and normal mice treated with inhibitors of the Notch-activating enzyme γ-secretase showed reduced damage to brain cells improved functional outcome in a model focal ischemic stroke. endangers neurons by modulating pathways that increase their vulnerability apoptosis, activating microglial stimulating infiltration proinflammatory leukocytes. These findings suggest signaling may be therapeutic target treatment stroke related neurodegenerative conditions.
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