Metabolic Syndrome and Inflammation

摘要: The “metabolic syndrome” is a cluster of cardiovascular disease (CVD) risk factors including abdominal obesity, hyperlipidemia, hypertension, insulin resistance, and hyperglycemia. These components reflecting overnutrition, sedentary lifestyles, resultant excess adiposity may associate with various conditions therefore multiple definitions were developed over time. prevalence metabolic syndrome increasing at rates paralleling the epidemic type 2 diabetes in USA as well rest world developing nations. Unlike autoimmune diabetes, accumulating evidence suggests that strongly linked to chronic systemic inflammation. presence associated an approximate doubling fivefold increased for incident diabetes. Although it unclear whether unifying pathophysiological mechanism results specific clinical clusters syndrome, subsequent inflammation oxidative stress resistance appear play central role. Landmark investigations inflammasome activity provide great potential insights into molecular basis inflammatory nature beginning story continues unfold. evolving concept hypertension having common provides new opportunities strategies, currently underway, correct consequences