Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health

摘要: Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog characterize genetic variation across well-chosen populations of canines necessary advance our understanding their evolutionary history architecture. To date, no organized effort has been undertaken sequence world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration researchers from globe who will generate 20× whole genomes 10 000 canids in 5 years. This capture diversity that underlies phenotypic geographical variability modern worldwide. Breeds, village dogs, niche extended pedigrees currently being sequenced, de novo assemblies multiple constructed. unprecedented dataset address underpinnings domestication, breed formation, aging, behavior morphological variation. More generally, this human canine health.