Identification of a Primary Target of Thalidomide Teratogenicity
作者： T. Ito , H. Ando , T. Suzuki , T. Ogura , K. Hotta
关键词:
摘要: Half a century ago, thalidomide was widely prescribed to pregnant women as a sedative but was found to be teratogenic, causing multiple birth defects. Today, thalidomide is still used in the treatment of leprosy and multiple myeloma, although how it causes limb malformation and other developmental defects is unknown. Here, we identified cereblon (CRBN) as a thalidomide-binding protein. CRBN forms an E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1) and Cul4A that is important for limb outgrowth and …
sciencemag.org
harvard.edu参考文章(35)
Toufan Parman, Michael J. Wiley, Peter G. Wells, Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity Nature Medicine. ,vol. 5, pp. 582- 585 ,(1999) , 10.1038/8466
Anne M. Moon, Mario R. Capecchi, Fgf8 is required for outgrowth and patterning of the limbs Nature Genetics. ,vol. 26, pp. 455- 459 ,(2000) , 10.1038/82601
Mark Lewandoski, Xin Sun, Gail R. Martin, Fgf8 signalling from the AER is essential for normal limb development. Nature Genetics. ,vol. 26, pp. 460- 463 ,(2000) , 10.1038/82609
S. Pajni-Underwood, C. P. Wilson, C. Elder, Y. Mishina, M. Lewandoski, BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling. Development. ,vol. 134, pp. 2359- 2368 ,(2007) , 10.1242/DEV.001677
Magda Melchert, Alan List, The thalidomide saga. The International Journal of Biochemistry & Cell Biology. ,vol. 39, pp. 1489- 1499 ,(2007) , 10.1016/J.BIOCEL.2007.01.022
ANDREA STREIT, Origin of the vertebrate inner ear: evolution and induction of the otic placode Journal of Anatomy. ,vol. 199, pp. 99- 103 ,(2001) , 10.1046/J.1469-7580.2001.19910099.X
R. J. D'Amato, M. S. Loughnan, E. Flynn, J. Folkman, Thalidomide is an inhibitor of angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 4082- 4085 ,(1994) , 10.1073/PNAS.91.9.4082
Stephane Angers, Ti Li, Xianhua Yi, Michael J MacCoss, Randall T Moon, Ning Zheng, None, Molecular architecture and assembly of the DDB1–CUL4A ubiquitin ligase machinery Nature. ,vol. 443, pp. 590- 593 ,(2006) , 10.1038/NATURE05175
Fumiaki Ohtake, Atsushi Baba, Ichiro Takada, Maiko Okada, Kei Iwasaki, Hiromi Miki, Sayuri Takahashi, Alexander Kouzmenko, Keiko Nohara, Tomoki Chiba, Yoshiaki Fujii-Kuriyama, Shigeaki Kato, Dioxin receptor is a ligand-dependent E3 ubiquitin ligase Nature. ,vol. 446, pp. 562- 566 ,(2007) , 10.1038/NATURE05683
Matthew D. Petroski, Raymond J. Deshaies, Function and regulation of cullin-RING ubiquitin ligases. Nature Reviews Molecular Cell Biology. ,vol. 6, pp. 9- 20 ,(2005) , 10.1038/NRM1547