The Role of Epigenetics in Cancer: From Molecular Function to High-Throughput Assays

摘要: The notion of epigenetics encompasses various modifications chromatin, including DNA methylation and post-translational histone proteins that can be stably transmitted through mitosis. Epigenetics plays a fundamental role in normal cell physiology as it is molecularly involved virtually all chromatin-associated processes, gene expression, replication repair. Alterations the global profile epigenetic are commonly observed cancer believed to associated with establishment clonal maintenance an aberrant expression pattern. Recent technological advances have enabled assess signature given type genome-wide manner. These comparative epigenome studies significantly increased our understanding oncogenic process. In addition, they constitute promising tools for improved classification diagnosis patients, ultimately leading design personalised therapies. this chapter, we focus on pathological development. We outline recent large-scale assays profiling tissue samples well pertinent new discoveries linking cancer.