Array-based DNA methylation profiling in follicular lymphoma
作者： L Bhaw-Rosun , C Fleischmann , C A Mein , T Crook , P Smith
DOI: 10.1038/LEU.2009.114
关键词:
摘要: Quantitative methylation profiling was performed using the Illumina GoldenGate Assay in untreated follicular lymphoma (FL) (164), paired pre- and post-transformation FL (20), benign haematopoietic (24) samples purified B T cells from two cases. Methylation values allowed separation of controls with one exception, based primarily on tumour-specific gains typically occurring within CpG islands. Genes that are targets for epigenetic repression stem by Polycomb Repressor Complex 2 were significantly over-represented among hypermethylated genes. profiles conserved sequential t-FL biopsies, suggesting widespread represents an early event lymphomagenesis may not contribute substantially to transformation. A significant (P<0.05) correlation between reduced gene expression shown up 28% loci. changes occurred predominantly variability amount non-malignant tissue preventing conclusive survival. This important caveat attributing prognostic relevance future studies cancer will optimally require tumour populations address impact clinical outcome.
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