Multiple capillary biochemical analyzer with barrier member

摘要: A multiple capillary biochemical analyzer for sequencing DNA and performing other analyses, in which a set of capillaries extends from wells (30) microtiter plate (32) into cuvette (22). In the (22) are held on fixed closely spaced centers by passing through sandwich construction having pair metal shims (64, 66) squeeze between them rubber gasket (84) forming leak proof seal an interior chamber ends positioned. Sheath fluid enters entrains filament sample streams capillaries. The streams, sheath fluid, flow aligned holes barrier member (90) close to ends, collection (102) lower glass window (100). illuminated above laser (130) causing fluoresce. fluorescence is viewed end-on CCD camera chip (138) located below arrangement ensures equal optical path length all fluorescing spots also blocks scattered illumination, providing more uniform results improved signal noise ratio.