A Polysomnographic Study of Parkinson’s Disease Sleep Architecture

摘要: Sleep disturbance is a common nonmotor phenomenon in Parkinson's disease (PD) affecting patient's quality of life. In this study, we examined the association between clinical characteristics with sleep disorders and architecture patterns PD cohort. Patients underwent standardized polysomnography study (PSG) their "on medication" state. We observed that male gender duration were independently associated obstructive apnea (OSA). Only lower levodopa equivalent dose (LED) was periodic limb movement (PLMD). REM behavior disorder (RBD) more among older patients, higher MDS-UPDRS III scores, LED. None investigated variables awakenings/arousals (A/A). efficiency predicted by amantadine usage age, while stage 1 dopamine agonists Hoehn & Yahr severity. The use MAO-B inhibitors part predictors stages 2 3. Age only predictor for total time. conclude are poorly predictable other related factors must also be contributing to these disturbances.