High-yield method for the production of human antibodies blocking the biological activity of a human cytokine
作者： Daniel Zagury , Helene Le Buanec , Bernard Bizzini
DOI:
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摘要: The invention concerns a pharmaceutical composition comprising, as the active ingredient, human natural antibodies of IgG isotype, that neutralize activity cytokine selected from VEGF, IFNα, IL-4, TNFα and TGFβ, said neutralizing inhibiting at least 50% maximum biological induced by an amount ranging 0.006 ng to 0.05 in vitro.
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