Does oligodendrocyte survival depend on axons

摘要: Abstract Background : We have shown previously that oligodendrocytes and their precursors require signals from other cells in order to survive culture. In addition, we about 50% of the produced developing rat optic nerve normally die, apparently a competition for limiting amounts survival factors. hypothesized axons may control levels such oligodendrocyte factors competition-dependent death serves match numbers number they myelinate. Here test one prediction this hypothesis — depends on axons. Results show occurs selectively transected nerves which degenerate. This cell is prevented by delivery exogenous ciliary neurotrophic factor (CNTF) or insulin-like growth I (IGF-1), both been promote vitro . also purified neurons Conclusion These results strongly suggest upon presence axons; support axon-dependent helps adjust myelination. The identities these remain be determined.