Experimental Design for the Optimization of Nanoscale Solid Lipid Particles Containing Rasagiline Mesylate

摘要: Background: The objective of this investigation was to design and optimize the fabrication Rasagiline mesylate loaded nanoscale solid lipid particles composed with stearic acid as matrix by microemulsion technique. (N-propargyl- 1-R-aminoindan) (RM) is a potent, selective, irreversible inhibitors monoamine oxidase-B, propargylaminebased drug. It has been explored in treatment Parkinson disease. Nanoscale are exploited carrier system for targeted drug delivery controlled manner. Method: Plackett-Burman successfully employed optimization containing mesylate. influence independent variables studied were lipid, surfactant co-surfactant concentration, volume aqueous phase, magnetic stirring rate, probe sonicator duration, beaker used cold phase. dependent variables, namely average particle size, span, surface area polydispersity index formulated nanoparticles. Results: experiments carried out according 12 runs involving 8 (higher lower levels) employing design. mesylate-loaded nanoparticles characterized mean it results 169 nm, 0.821, 52.4 m 2 g -1 0.310, respectively. morphological evaluation optimal found be monodisperse, uniform size quasispherical shape smooth transmission electron microscopy (TEM). selected diffraction (SAED) indicated formulation not an amorphous form but crystalline state. Conclusion: experimental good correlated predicted data analysed statistical method. Key words: Plackett-Burman, mesylate, Ransmission microscopy, Selected diffraction, Solid