Design of Lipid-Based Formulations for Oral Administration of Poorly Water-Soluble Drug Fenofibrate: Effects of Digestion

摘要: Lipid-based drug carriers are likely to have influence on bioavailability through enhanced solubilization of the in gastrointestinal tract. The study was designed investigate lipid formulation digestibility simulated gastro intestinal media. Fenofibrate formulated representative Type II, IIIA, IIIB and IV self-emulsifying/microemulsifying delivery systems (SEDDS SMEDDS for oral administration) using various medium-chain glyceride components, non-ionic surfactants cosolvents as excipients. Soybean oil used only an example long-chain triglycerides compare effects with their counterparts. formulations were subjected vitro digestion specifically predict fate tract after exposure pancreatic enzymes bile. In experiments carried out a pH-stat maintained at pH 7.5 30 min fluids simulating fed fasted states. rate faster almost completed II IIIA systems. Most studies digestible. However, high concentration surfactant and/or cosolvent or lowered digestion. than triglycerides, but kept comparatively less post products. Medium-chain mixed glycerides good solvents fenofibrate rapidly digested improve products use suggested further investigations.