Nanostructured lipid carriers versus microemulsions for delivery of the poorly water-soluble drug luteolin

摘要: Abstract Objective Nanostructured lipid carriers and microemulsions effectively deliver poorly water-soluble drugs. However, few studies have investigated their ability difference in improving drug bioavailability, especially the factors contributed to difference. Thus, this study was aimed at investigating efficiency bioavailability enhancement based on studying two key processes that occur NLC ME during traverse along intestinal tract: solubilization process permeability process. Methods The nanostructured had same composition except former were prepared with solid lipids latter liquid lipids; both evaluated for particle size zeta potential. Transmission electron microscopy, differential scanning calorimetry, X-ray diffraction performed characterize properties. Furthermore, vitro release, situ absorption, lipolysis studied. of luteolin delivered using rats compared suspensions. Results analysis revealed different release mechanisms microemulsions, although absorption similar. data indicated digestion speed extent higher than carriers, more partitioned aqueous phase. vivo oral those Conclusion improved luteolin’s rats. rapid much solubilized available may contribute better bioavailability.