Synthesis and biological evaluation of novel luteolin derivatives as antibacterial agents.
作者： Peng-Cheng Lv , Huan-Qiu Li , Jia-Yu Xue , Lei Shi , Hai-Liang Zhu
DOI: 10.1016/J.EJMECH.2008.01.013
关键词:
摘要: Abstract A series of luteolin derivatives 2–20 were prepared, 3–20 which first reported. The chemical structures these compounds confirmed by means 1H NMR, ESI-MS and elemental analyses. assayed for antibacterial (Bacillus subtilis, Staphylococcus aureus, Pseudomonas fluorescens Escherichia coli) activities MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl trtrazolium bromide) method. Among the tested, most them displayed significant activity against tested strains, 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-hydroxy-7-(2-(3-morpholinopropylamino)ethoxy)-4H-chromen-4-one (17) showed favorable in vitro with MICs 1.562, 3.125, 6.25 μg/mL B. S. P. E. coli, respectively. Structure–activity relationships (SAR) also discussed based on obtained experimental data.
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