Long-term effects of neonatal exposure to MK-801 on recognition memory and excitatory-inhibitory balance in rat hippocampus.

摘要: Blockade of the N-methyl-d-aspartate receptors (NMDARs) during neonatal period has been reported to induce long-term behavioral and neurochemical alterations that are relevant schizophrenia. In this study, we examined effects such treatment on recognition memory hippocampal excitatory inhibitory (E/I) balance in both adolescence adulthood. After exposure NMDAR antagonist, MK-801, at postnatal days (PND) 5-14, male Sprague-Dawley rats were tested for object object-in-context (PND 35) adulthood 63). The parvalbumin-positive (PV+) γ-aminobutyric acid (GABA)-ergic interneurons presynaptic markers neurons, vesicular glutamate transporter-1 (VGLUT1) GABA transporter (VGAT) hippocampus reflect E/I balance. We found receiving MK-801 showed deficits memory, reduction PV+ cell counts upregulation VGLUT1/VGAT ratio Notably, changes two time points exhibited distinct mechanisms. These results parallel findings abnormalities schizophrenia lend support usefulness blockade as a potential neurodevelopmental model disease.