Transient N-methyl-D-aspartate receptor blockade in early development causes lasting cognitive deficits relevant to schizophrenia
作者： Mark Renato Stefani , Bita Moghaddam
DOI: 10.1016/J.BIOPSYCH.2004.11.031
关键词:
摘要: Background: Aberrant N-methyl-D-aspartate (NMDA) receptor-mediated glutamatergic transmission has been implicated in schizophrenia. We studied whether transient inhibition of NMDA receptor activity during early postnatal development would produce a behavioral phenotype resembling that individuals who are susceptible to develop Methods: Rat pups were given injections the channel blocker MK801 on days 7 through 10. This period is akin prenatal second trimester primate development. Cognitive function was tested adulthood. Results: Treatment with impaired cognitive flexibility and working memory. The impairment due increased perseverative behavior. did not affect locomotor or recognition Conclusions: These results suggest brief disruption receptors sensitive cortical sufficient selective deficits relevant
elsevier.com
sci-hub.se 参考文章(31)
Liane N. Rotta, André P. Schmidt, Tadeu Mello e Souza, Cristina W. Nogueira, Karine B. Souza, Ivan A. Izquierdo, Marcos L. S. Perry, Diogo O. Souza, Effects of Undernutrition on Glutamatergic Parameters in Rat Brain Neurochemical Research. ,vol. 28, pp. 1181- 1186 ,(2003) , 10.1023/A:1024272227219
Wisconsin Card Sorting Test performance in schizophrenia: remediation of a stubborn deficit. American Journal of Psychiatry. ,vol. 149, pp. 62- 67 ,(1992) , 10.1176/AJP.149.1.62
Frans van Haaren, Methods in behavioral pharmacology Elsevier. ,(1993)
Ann E. Kelley, Locomotor activity and exploration Techniques in The Behavioral and Neural Sciences. ,vol. 10, pp. 499- 518 ,(1993) , 10.1016/B978-0-444-81444-9.50024-9
Andreas Lüthi, Lucia Schwyzer, José María Mateos, Beat H. Gähwiler, R. Anne McKinney, NMDA receptor activation limits the number of synaptic connections during hippocampal development. Nature Neuroscience. ,vol. 4, pp. 1102- 1107 ,(2001) , 10.1038/NN744
Barbara K. Lipska, Nader D. Halim, Pavan N. Segal, Daniel R. Weinberger, Effects of Reversible Inactivation of the Neonatal Ventral Hippocampus on Behavior in the Adult Rat The Journal of Neuroscience. ,vol. 22, pp. 2835- 2842 ,(2002) , 10.1523/JNEUROSCI.22-07-02835.2002
Mark R. Stefani, Karyn Groth, Bita Moghaddam, Glutamate receptors in the rat medial prefrontal cortex regulate set-shifting ability. Behavioral Neuroscience. ,vol. 117, pp. 728- 737 ,(2003) , 10.1037/0735-7044.117.4.728
Ratna Sircar, Postnatal phencyclidine-induced deficit in adult water maze performance is associated with N-methyl-D-aspartate receptor upregulation. International Journal of Developmental Neuroscience. ,vol. 21, pp. 159- 167 ,(2003) , 10.1016/S0736-5748(03)00026-1
Laura Wiseman Harris, Trevor Sharp, Jane Gartlon, Declan N. C. Jones, Paul J. Harrison, Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism. European Journal of Neuroscience. ,vol. 18, pp. 1706- 1710 ,(2003) , 10.1046/J.1460-9568.2003.02902.X
PJ Harrison, MJ Owen, Genes for schizophrenia The Lancet. ,vol. 361, pp. 1829- 1830 ,(2003) , 10.1016/S0140-6736(03)13434-4