COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study

摘要: Objective Obsessive-compulsive disorder (OCD) is a common and debilitating psychiatric illness. Although genetic component contributes to its etiology, no single gene or mechanism has been identified the OCD susceptibility. The catechol-O-methyltransferase (COMT) monoamine oxidase A (MAO-A) genes have investigated in previous studies, but results are still unclear. More recently, Taylor (2013) comprehensive meta-analysis of association studies COMT MAO-A polymorphisms involved with OCD. In an effort clarify role these two vulnerability, family-based investigation was performed as alternative strategy classical case-control design. Methods Transmission disequilibrium analyses were after genotyping 13 single-nucleotide (eight five MAO-A) 783 trios (probands their parents). Four different phenotypes (from narrow broad definitions) SNP x epistasis also analyzed. Results OCD, phenotypes,were not associated any polymorphisms. addition, gene-gene interaction did show significant epistatic influences on phenotype between MAO-A. Conclusions findings do support DSM-IV variants However, from this study cannot exclude contribution manifestation evaluation broader spectrum could help understand other pathophysiology disorders.