No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene. Biomed European Bipolar Collaborative Group
作者： Nick Craddock , Gillian Spurlock , Peter Mcguffin , Michael J. Owen , Marika Nosten-Bertrand
关键词:
摘要: BACKGROUND There is compelling evidence for the existence of susceptibility genes bipolar disorder. Association studies using functional DNA variations are an important approach identifying these genes. The enzyme catechol-O-methyltransferase (COMT) plays a key role in degradation catecholamine neurotransmitters and candidate involvement Recently common genetic polymorphism that underlies population variation COMT activity has been elucidated simple assay developed. METHOD In collaboration involving seven European centres, we have undertaken association study this 412 unrelated West caucasian DSM-III-R patients 368 ethnically matched controls. RESULTS We found no allelic or genotypic association. CONCLUSIONS can conclude at does not make contribution to disorder Western population. Future powerful experimental be expected contribute identification
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