COMT: a common susceptibility gene in bipolar disorder and schizophrenia.
作者： Sagiv Shifman , Michal Bronstein , Meira Sternfeld , Anne Pisanté , Avraham Weizman
DOI: 10.1002/AJMG.B.30032
关键词:
摘要: A variety of psychiatric illnesses, including schizophrenia and bipolar disorder, have been reported in patients with microdeletion on chromosome 22q11-a region which includes the catechol-O-methyltransferase (COMT) gene. The manifestations 22q11 role COMT degradation catecholamine neurotransmitters may thus suggest a general involvement gene diseases. We previously significant association between haplotype schizophrenia. In this study, we attempt to test for disorder polymorphisms implicated was tested by examining allele found be associated found. estimated relative risk is greater women, result consistent our previous findings that influence susceptibility both diseases--and probably also wider range behavioral traits.
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